High Dose Consensus Interferon in Nonresponders to Interferon Alpha-2B and Ribavirin with Chronic Hepatitis C
نویسندگان
چکیده
منابع مشابه
EFFICACY AND SAFETY OF COMBINATION THERAPY OF INTERFERON-ALPHA 2B PLUS RIBAVIRIN FOR CHRONIC HEPATITIS C
Introduction: The aim of this study is to assess the therapeutic efficacy and safety of a particular brand of IFN alpha (PDferon B®) in combination with ribavirin (RlBA) on Iranian patients with chronic hepatitis C (CHC). The addition of RIBA to the standard treatment with interferon (IFN) alpha led to an improvement in sustained virologic response (SVR) from less than 20% with IFN monother...
متن کاملRetreatment with interferon-alpha and ribavirin in primary interferon-alpha non-responders with chronic hepatitis C.
BACKGROUND/AIMS Combination therapy with interferon-alpha (IFN-alpha) plus ribavirin is more efficacious than IFN-alpha monotherapy in previously untreated patients with chronic hepatitis C and patients with IFN-alpha relapse. Only limited data are available in IFN-alpha non-responders. In a multicenter trial we therefore evaluated the efficacy of combination therapy in IFN-alpha-resistant chro...
متن کاملAdding ribavirin to interferon alpha-2b for chronic hepatitis C infection increased virological response and nausea.
Patients 100 patients (mean age 40 y, 62% men) who had increased aminotransferase concentrations for >6 months, serum antibodies to HCV found by polymerase chain reaction (PCR), and a diagnosis of chronic hepatitis on a liver biopsy sample in the previous 12 months. Exclusion criteria included previous treatment with interferon á-2b or ribavirin, decompensated cirrhosis, autoimmune hepatitis, c...
متن کاملInterstitial pneumonitis after combination therapy with pegylated interferon alpha-2b and ribavirin for chronic hepatitis C.
Pulmonary toxicity is a rare but potentially fatal side effect occurring during interferon (IFN) alpha treatment for chronic hepatitis C. We present a 47-year-old woman who had chronic hepatitis C and was treated with pegylated IFN alpha-2b in combination with ribavirin, with a good virological response by week 10 of therapy. Then the patient began to complain of dyspnea on exertion and a dry c...
متن کاملTreatment of chronic hepatitis C with recombinant interferon alpha 2b.
The authors studied 70 patients affected by chronic hepatitis C where diagnosis had been made by clinical and histological tests. Intramuscular recombinant alpha 2b interferon (3 x 10(6)) was administered to 35 patients every second evening for 6 months, whereas the other 35 received aspecific treatment. Our results revealed normalization of transaminase in 57% of the patients, with distinct im...
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ژورنال
عنوان ژورنال: Canadian Journal of Gastroenterology
سال: 2003
ISSN: 0835-7900
DOI: 10.1155/2003/131943